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These results suggest that GGCT knockdown can significantly inhibit tumor growth and reduce GSH production and that the addition of the ROS inhibitor NAC can significantly rescue this effect

At the family level (Figure S6A), the network showed high complexity, with Sutterellaceae serving as a central node highly connected to Prevotellaceae and Lachnospiraceae

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Parker M., Sawant H.B., Flannery T., Tarrant R., Shardha J., Bannister R., Ross D., Halpin S., Greenwood D.C., Sivan M

294 VancampfortD.FirthJ.SchuchF

Results GSH synthesis is required for the survival of adult animals To better understand the importance of GSH in adult mammals, we developed an inducible, whole-body Gclc KO mouse by breeding the Gclc f/f mouse strain 30 with the Rosa26-CreERT2 mouse strain 31